Although most of the adverse events reported were already known, unexpected events such as dementia,44 low-motility sperm,46 miscarriage, proliferative changes,5 increased levels of chromogranin A,79 increased levels of fibroblast growth factor 2,72 chills, cardiovascular events (myocardial infarction, heart failure, stroke, ischemic stroke, pulmonary embolism and thrombosis),47 scarlet fever, hyperglycemia, mononucleosis infection, gastrointestinal bleeding, nasopharyngitis, otitis media, loss of libido and rhinitis have also been identified.4 This evidence concerns the gene FGF2 and heart failure.