To our knowledge, only 7 patients with SFMS have been molecularly analyzed to date (Table 2) and identified mutations include HRAS c.37G>C (p.Gly13Arg) in three patients (Groesser et al., 2012; Lihua et al., 2017; Sun et al., 2013), KRAS c.35G>A (p.Gly12Asp) in two subjects, KRAS c.34G>T (p.Gly12Cys) in a single patient (Groesser et al., 2012; Igawa et al., 2016), and NRAS c.182 A>G (p.Gln81Arg) in another patient (Kuroda et al., 2015). This evidence concerns the gene NRAS and intellectual disability-hypotonic facies syndrome, X-linked, 1.