Multiple comorbidities, polypharmacy and increased use of concomitant medications in older individuals with T2D may increase the risk of hypoglycaemia, and insulin metabolism may alter with age.35 In particular, a greater prevalence and severity of renal insufficiency in older individuals and a greater frequency of visual and/or cognitive impairment may interfere with routine self‐care in individuals with diabetes.22, 36, 37 Frailty37 can compound the burden of self‐management in older individuals and increase hypoglycaemia risk. The gene discussed is INS; the disease is Renal insufficiency.