ORMDL3 and asthma: Importantly, the genome locus of GSDMB and orosomucoid 1‐like 3 (ORMDL3) on chromosome 17q21 is strongly associated with childhood‐onset asthma.190, 191 GSDMB is highly expressed in airway epithelial cells.192 GSDMB‐mediated pyroptosis in epithelial cells may be involved in the pathogenesis of asthma.