Importantly, the genome locus of GSDMB and orosomucoid 1‐like 3 (ORMDL3) on chromosome 17q21 is strongly associated with childhood‐onset asthma.190, 191 GSDMB is highly expressed in airway epithelial cells.192 GSDMB‐mediated pyroptosis in epithelial cells may be involved in the pathogenesis of asthma. This evidence concerns the gene GSDMB and Onset.