Proinflammatory markers such as tumor necrosis factor alpha (TNF-α), IL-1β a, cyclooxygenase (COX-2) and Monocyte Chemoattractant Protein-1(MCP-1), and profibrotic factors, including TGF-β1, α-SMA, and Smad2/4 expression were significantly raised in NASH rats, but this rise was either eliminated or attenuated significantly in both LBP-treated groups. The gene discussed is SMAD2; the disease is metabolic dysfunction-associated steatohepatitis.