In subgroup analyses, high PD-L2 expression revealed an unfavorable prognostic prediction for OS in hepatocellular carcinoma (HCC) (HR = 1.60, 95% CI = 1.12–2.29, P = 0.011) and for DFS/PFS in HCC (HR = 1.50, 95%CI = 1.04–2.16, P = 0.031) as well as clear cell renal cell carcinoma (HR = 1.45, 95% CI = 1.03–2.03, P = 0.033). The gene discussed is PDCD1LG2; the disease is clear cell renal carcinoma.