Importantly, we found the UGT1A1 IC50 value for 2,3-dehydrosilybin A even lower than that reported for atazanavir (2.3 μmol/L), the well-known hyperbilirubinemia-inducing drug [40] indicating the high bilirubinemia-enhancing potential of this flavonolignan. This evidence concerns the gene UGT1A1 and Hyperbilirubinemia.