These authors reported that EP effectively inhibited HMGB1 localization and secretion in MM cell lines REN and HP3 (also referred to as Phi), and they utilized REN and HP3 cells to demonstrate that EP suppressed the viability, motility, migration, and anchorage-independent growth of MM cells by hampering HMGB1 release mediated through inhibition of NF-κB nuclear translocation [81]. This evidence concerns the gene HMGB1 and Miyoshi myopathy.