HMGB1 and macrophage activation syndrome: According to the current literature, hyperacetylated HMGB1 has only been detected in blood from patients with alcoholic liver disease [61], acute acetaminophen-induced liver failure [62], severe macrophage-activation syndrome [63], and drug-resistant epilepsy [64], and few epidemiological studies have described hyperacetylated HMGB1 levels in blood samples in patients with cancers other than MM.