In MM studies, Jube et al. demonstrated that anti-HMGB1 neutralizing mAbs inhibited the activity of HMGB1 in REN cells and primary HM cells, blocked the HMGB1-RAGE interaction, and suppressed the MM malignant phenotype in severe combined immunodeficiency (SCID) mice with human MM xenografts [44]. The gene discussed is HMGB1; the disease is Miyoshi myopathy.