Similarly, we found that in a Chinese Han population, HMGB1 levels in an MPM group were significantly higher than those of healthy control, AE and pleural plaque groups, with an AUC of 0.94 (95% CI: 0.89-1.03) for the ability of HMGB1 to distinguish MPM patients from healthy controls [59], though the AUCs for AE individuals with <10 years of exposure and ≥10 years of exposure were 0.81 (95% CI: 0.73-0.90) and 0.80 (95% CI: 0.72-0.89), respectively [59]. This evidence concerns the gene HMGB1 and pleural disorder.