Notably, compared with normal healthy cells, a number of solid tumor cells exhibit increased expression and secretion of HMGB1, particularly in inflammation-associated cancers, such as hepatocellular carcinoma [35–37], colorectal cancer [38, 39], cervical carcinoma [40, 41], and MM [42–44], and high levels of HMGB1 are correlated with a poor clinical prognosis. This evidence concerns the gene HMGB1 and hepatocellular carcinoma.