HMGB1 and cancer: In fact, HMGB1 has been found to induce EMT in chronic inflammation-associated cancers, including colorectal carcinoma [55], intrahepatic cholangiocarcinoma [56], gastric cancer [57], cervical carcinoma [40], and MM [46, 58], and recent work supports the occurrence of HMGB1-induced EMT in HM cells exposed to asbestos, as well as in MM cancer cells.