BDNF and amyotrophic lateral sclerosis: Potenza et al. demonstrated that the antineuroinflammatory factor fingolimod phosphate (FTY720), which acts as an immunomodulator, significantly modulated neuroinflammatory and protective genes (CD11b, Foxp3, iNOS, Il1β, Il10, Arg1, and Bdnf) by controlling activation of microglia in the motor cortex and spinal cord in animals with ALS [41].