Thus far, the SOD1, TAR DNA-binding protein 43 (TDP-43), Alain (Als2), fused in sarcoma (FUS), optineurin (OPTN), Ubiquilin2 (UBQLN2), and C9ORF72 genetic mutations [3–8] have been investigated for their causal relationship with ALS. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.