MADCAM1 and inflammatory bowel disease: The partial reservation of ILC3s seeding (with the potential of perpetuating the intestinal lymphoid neogenesis) to mucosal locations or for LTi subset of ILC3s in embryonic lymph node anlage even in the complete absence of MAdCAM-1 may reflect some degree of endothelial plasticity in addressin display, which may question the efficacy of anti-adhesion therapeutic interventions in IBD.