Based on this knowledge, common clinical criteria for CM-HUS include: (1) a serum creatinine level at or above the upper limit of the normal range, (2) microangiopathic hemolytic anemia, (3) thrombocytopenia, (4) ADAMTS13 activity of 5% or more, (5) and negative stool tests for Shiga toxin–producing infection (14). The gene discussed is ADAMTS13; the disease is hemolytic-uremic syndrome.