The clinical presentation of these primary immunodeficiencies (PIDs) may include recurrent upper respiratory tract infections often leading to bronchiectasis, humoral immunodeficiency with elevated IgM, diffuse lymphadenopathy, Epstein Barr virus, and/or cytomegalovirus viremia, and an increased risk of lymphoma (8, 9). The gene discussed is CD40LG; the disease is Recurrent upper respiratory tract infections.