GPC3 and cancer: While the role of GPC3 as a cancer marker and during liver proliferation, regeneration, and repair has been described (Jakubovic and Jothy, 2007; Liu et al., 2009; Liu et al., 2010), GPC3 is not canonically thought to be expressed in adult hepatocytes at homeostasis (Capurro et al., 2003; Yamauchi et al., 2005).