In this regard, since it is well-documented that an increase in BDNF content in the NAcc increases cocaine-seeking behavior (Graham et al., 2007; Bahi et al., 2008) and vulnerability to substance abuse (Krishnan et al., 2007; Burke and Miczek, 2015), an increase in proBDNF in this brain area could have an opposite impact. The gene discussed is BDNF; the disease is substance abuse.