According to the classical mechanism mentioned above, as the transcriptional switch for STAT6-dependent gene expression, PARP14 takes advantage of mono-ADP-ribosyltransferase activity to mediate transcription of target genes involved in growth and proliferation of tumor cells (Goenka and Boothby, 2006; Goenka et al., 2007; Mehrotra et al., 2011). Here, PARP14 is linked to neoplasm.