Investigations on metastatic PCa (mPCa) cell lines have revealed that PARP14, together with deltex-3-like E3 ubiquitin ligase (DTX3L) and PARP9, promoted mPCa cell survival and proliferation by forming complexes, which implies that the catalytic activity of PARP14 is indispensable for the survival of mPCa cells. This evidence concerns the gene DTX3L and posterior cortical atrophy.