NFE2L2 and brain ischemia: Following cerebral ischemia injury with reperfusion, several studies showed that Nrf2−/− mice exhibited aggravated acute brain damage in infarct volume and neurological deficits scores at 1 day after tMCAO with 1 h (Li et al., 2013; Yao et al., 2016; Zhang et al., 2017), 1.5 h (Shah et al., 2007), and 2 h (Shi et al., 2015) of ischemia.