NFE2L2 and Stroke: Given that the ARE-regulated genes are preferentially activated in glial cells, which have more effective detoxification and antioxidant capacities than neurons (Vargas and Johnson, 2009; Gan et al., 2012; Haskew-Layton et al., 2013), Nrf2 in glia cells can protect neurons from a wide array of insults like stroke (Vargas and Johnson, 2009).