However, phosphorylation of tau was markedly increased at Ser202/Thr205 (AT8), Thr217, Ser262 and Ser422 (Figures 2A,B), was slightly increased at Thr212 and Ser214 (Figures 2A,B), and was not altered at Ser199, Ser396 and Ser404 (Figures 2C,D) in the AD P-tau injected hippocampus in Tg/hTau mice. This evidence concerns the gene MAPT and Alzheimer disease.