Similarly, other kinases, including Cdk5, Erk1, Jnk/SAPK, Dyrk1A, P70S6K, AMPK, AKT, and CK1ε, may not be involved in AD P-tau-induced hyperphosphorylation was evidenced by the site-specific phosphorylation and their expression levels. This evidence concerns the gene MAPK8 and Alzheimer disease.