SDS- and β-mercaptoethanol-resistant HMW-tau aggregates were present in SI-tau and AD P-tau, but not in HS-tau (Figure 8A), confirming aggregated tau in SI-tau and AD P-tau and the non-aggregated nature of HS-tau (Grundke-Iqbal et al., 1986a; Greenberg and Davies, 1990). Here, MAPT is linked to Alzheimer disease.