To learn that SDS- and β-mercaptoethanol-resistant AD-like HMW-tau in the AD P-tau-injected hippocampus is not the injected exogenous AD P-tau, we analyzed ipsilateral hippocampus of Tg/hTau and Tau−/− mice injected with AD P-tau by Western blots developed with various anti-phospho-tau antibodies. Here, MAPT is linked to Alzheimer disease.