AKT1 and Alzheimer disease: Furthermore, the active form of AMPK (phosphorylated AMPK at Thr172), PKA catalytic subunit, active form of AKT (phosphorylated at Ser473), active form of P70S6K (phosphorylated P70S6K at Thr389), and CK1ε were also not changed in AD P-tau-injected hippocampus as compared with those in corresponding controls (Figure 7C), indicating that these non-PDPKs may not be responsible for the hyperphosphorylation of tau too.