B1R blockade mitigated cognitive deficits by B1R antagonist des-Arg9[Leu8]-bradykinin in Aβ-treated mice (Prediger et al., 2008) and in rat (Bitencourt et al., 2017), and by B1R antagonist SSR240612 in Tg-SwDI mice of AD (Lacoste et al., 2013). The gene discussed is BDKRB1; the disease is Alzheimer disease.