Analysis of FDDKI and FBDKI mice, two knock-in mouse models of FDD and FBD that carry one mutant and one wild-type Itm2b allele, has shown that the Danish and British mutations cause the loss of Bri2 protein, LTP deficits and memory impairments; interestingly, these alterations are APP-dependent9–15. This evidence concerns the gene ITM2B and ABri amyloidosis.