TGFB1 and osteoarthritis: Using Ingenuity Pathway Analysis (IPA), we found six enriched canonical pathways (p < 0.05, right-tailed Fisher’s Exact test with B-H multiple comparison correction), all very relevant to osteoblastic differentiation: role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis, osteoarthritis pathway, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, BMP signaling pathway, TGF-β signaling, and Wnt/β-catenin signaling (Supplementary Figure 5).