TET2 and cyclic hematopoiesis: In addition to CH, somatic frameshift, nonsense, and missense TET2 mutations are commonly seen for example in myelodysplastic syndrome (6–26% prevalence), acute myeloid leukemia (AML; 12–27% in adult de novo AML), chronic myelomonocytic leukemia (20–58%), and angioimmunoblastic T-cell lymphoma (33–83%)8.