In addition, the elderly mutation carriers (Ly1, Ly2, Ly9, and Ly11, aged 36–64 years) exhibited skewing of CD3+CD8+ T cells toward increased proportions of the CD3+CD8+CCR7−CD45RA+ terminally differentiated effector memory cells re-expressing CD45RA (TEMRA) phenotype, which in the absence of chronic viremia or lymphopenia suggests immune exhaustion. The gene discussed is CD8A; the disease is lymphopenia.