Analysis of regulon activity by looking at TFs and their co-expressed cis target genes revealed 26 TFs with significantly increased and 12 TFs with significantly decreased activity in cancer-free TET2delA carriers as compared to wild-type individuals, including TBX21 and EOMES that displayed lower activity especially in CD8+ T cells and NK cells (Supplementary Fig. 17, Supplementary Data 3 and 4). The gene discussed is CD8A; the disease is cancer.