TIAM1 and colorectal carcinoma: Next, to examine whether the expression of TIAM1 correlates with therapeutic response, we investigated TIAM1 mRNA expression in two independent CRC cohorts, which included patients that were responders or non-responders to FOLFOX (GSE28702, n = 50) and FOLFIRI (GSE62080, n = 21; Fig. 1a, b).