In a Cox proportional hazard regression analysis, high-TIAM1 expression emerged as an independent prognostic factor for poor survival (HR, 4.18; 95% CI 1.18–14.77; P = 0.027) and higher recurrence rate (HR, 5.06; 95% CI 1.10–23.24; P = 0.038; Fig. 1e) in CRC patients. Here, TIAM1 is linked to colorectal carcinoma.