In this present study, we show that modulation of LRRK2 through deletion (KO), inhibition (de-phosphorylation) or mutagenesis of LRRK2 alters the mitochondrial Ca2+ efflux; therefore linking another PD risk gene to NCLX leading to decreased PTP opening threshold and an increased dopamine-induced neuronal death (Figs. 1, 2, 5). The gene discussed is LRRK2; the disease is Parkinson disease.