In this current study expression of the constitutively active phosphomimetic mutant of NCLX (NCLXS258D) also rescued the mitochondrial Ca2+ efflux in LRRK2 mutation bearing fibroblast and LRRK2 inhibitor treated cells in a similar manner previously described in a PINK PD model16,45 (Fig. 3). Here, LRRK2 is linked to Parkinson disease.