Fibroblast from patients bearing either LRRK2 G2019S (kinase domain), R1441G (ROC domain) or Y1699C (COR domain) mutation and unaffected controls were employed to assess whether mitochondrial Ca2+ buffering was a common phenotype in PD as well as LRRK2 deficiencies. Here, LRRK2 is linked to Parkinson disease.