While the UAF1-USP12 and UAF1-USP46 complexes regulate histone deubiquitination (15) and the cell survival- and growth-promoting Akt pathway (16, –, 20), the UAF1-USP1 complex is involved in the Fanconi anemia (FA) DNA repair pathway (21). The gene discussed is WDR48; the disease is Fanconi anemia.