Of note, we could only demonstrate a minimal overlap between these gene sets (11/496 genes, ∼2%) and similarly, when we compared our genes de-repressed during induction with a published dataset documenting genes de-repressed following genetic loss of Ezh2 during the maintenance of MLL-AF9 AML, the overlap was also low (Tanaka et al., 2012; 60/496 genes, ∼12%). Here, MLLT3 is linked to acute myeloid leukemia.