Comparing the de-repressed candidate genes in each condition, within the overlapping genes (Fig. 5 a), a few select candidate genes were up-regulated across multiple conditions, notably Plag1 (common to all), a transcription factor with known oncogenic roles in CBFB-MYH11 murine leukemias (Castilla et al., 2004; Landrette et al., 2005), and the well-characterized oncogenic RNA-binding protein Lin28b (common to premalignant and MLL-AF9 comparisons), which has also been demonstrated to play a role in the acceleration of JAK2-V617F–driven myelofibrosis following Ezh2 loss (Shimizu et al., 2016). Here, EZH2 is linked to myelofibrosis.