EZH2 and acute myeloid leukemia: However, EZH2 mutations have been previously documented to occur in older patients and those with secondary AML or “MDS-like” AML, subgroups associated with a poorer survival and less likely to receive intensive therapy (Ernst et al., 2010; Nikoloski et al., 2010; Lindsley et al., 2015; Saygin et al., 2018).