Previously, we have shown that overexpression of PGE2 induces WNT and NOTCH pathway genes in human breast cancer and PGE2 induces cancer stem-like cells (SLCs), which were abrogated with NOTCH/Wnt and PI3K/Akt and Erk inhibitor treatments (Majumder et al., 2016). This evidence concerns the gene AKT1 and breast carcinoma.