IL1R1 and neoplasm: Using the IL-1R1 knockdown SQ20B cells shown in Fig.S 1G-I in athymic nude mice, we showed that knocking down the IL-1R1 using both clones (shIL-1R#1 and shIL-1R#2) did not enhance but partially and significantly reversed the anti-tumor effect of cetuximab (Additional file 9: Figure S8).