We found that the IL-1α-overexpressing tumors treated with cetuximab (#20 CTX) grew significantly slower compared to the IgG (#16 IgG) and cetuximab-treated (#16 CTX) control clones, and the IgG-treated IL-1α-overexpressing clones (#20 IgG) (Fig. 3) suggesting that increased tumor-derived IL-1α may enhance tumor response to cetuximab. This evidence concerns the gene IL1A and neoplasm.