In the Additional file 1: Text we discuss new and notable candidates (e.g., MYCN, EWSR1 retrogene, MIR100HG, and MTMR9), new evidence implicating one of multiple candidates at a locus (TANGO2), members of gene families that contain other genes known to be cancer drivers and prominent osteosarcoma pathways that are represented by multiple candidates. The gene discussed is TANGO2; the disease is cancer.