APOC2 and pancreatitis: The second most frequently reported cause of chylomicronaemia, often resulting in severe pancreatitis, is the presence of homogeneous APOC2 loss-of-function mutations.120 Indeed, several case reports indicate chylomicronaemia and decreased concentrations of apoCII in individuals with APOC2 loss-of-function mutations.121, , , –125 However, so far, these numbers are too small for full observational studies, and MRTs have not yet been conducted.