reported that increased apoCII concentrations are associated with CHD after adjustment for cardiovascular risk factors in a case–control study including 352 CHD patients and 395 controls.157 This evidence supports an association between apoCII and CVD risk, but causality between apoCII concentrations and CVD was not established.66 Interestingly, we recently identified a phenotype of relatively young women with a combination of very low apoCII (≤5 mg/L), normal TG concentrations, and low concentrations of LDL-C, apoB100, and apoE who presented with STEMI. The gene discussed is APOE; the disease is coronary artery disorder.