A higher apoB100/apoA-I ratio likely indicates that more atherogenic particles are circulating in plasma leading to more plaque build-up in arteries, atherosclerosis and higher risk of CVD events.154 Compared to other lipid ratios, the apoB100/apoA-1 ratio may be more accurate in risk prediction, particularly among high-risk individuals, than high LDL-C and low HDL-C concentrations.155 Concordantly, we reported recently that the apoB/apoA-1 ratio was strongly associated with risk of ST-segment elevation myocardial infarction (STEMI) (Figure 5(c)).156. The gene discussed is APOA1; the disease is atherosclerosis.