APOE and coronary artery disorder: In addition, apoE4 is proposed to be an independent risk factor for CHD regardless of its effect on plasma cholesterol concentrations.92, –94 On the other hand, homozygotes of apoE2, insofar as they do not develop type III hyperlipoproteinaemia (also called dysbetalipoproteinaemia), show lower plasma total cholesterol and LDL-C concentrations, lower apoB100 concentrations, and higher plasma TG concentrations than homozygotes of apoE3.