Individuals with a loss-of-function mutation in the apoB gene typically have familial hypercholesterolemia (FH), which is characterized by substantially elevated concentrations of LDL-C and early-onset CVD, specifically CAD (e.g. Pang et al.119), further validating the causative role for apoB in CVD. The gene discussed is APOB; the disease is familial hyperaldosteronism.