Thus, compared with treatment with a statin later in life, prolonged exposure to lower LDL-C beginning early in life was associated with a two- to three-fold greater reduction in the risk of CHD for each unit lower LDL-C (Figure 3).129,141 This was further corroborated by Kathiresan et al., who monitored the same APOE rs4420638 SNP to study the relation between LDL-C and CVD risk in the Malmo ̈ Diet and Cancer Study.117. Here, APOE is linked to coronary artery disorder.