VEGFA and ovarian cancer: During the last 10 years, bevacizumab, a monoclonal antibody that binds to vascular endothelial growth factor (VEGF), has revolutionized the treatment approach in ovarian cancer, obtaining US Food and Drug Administration (FDA)/ European Medicines Agency (EMA) approval in all advanced disease settings (multi-treated/compassionate, platinum-resistant/platinum-sensitive recurrent, and primary International Federation of Gynecology and Obstetrics (FIGO) stage IIIB-IV ovarian cancer) (www.fda.gov; www.ema.europa.eu).