In athymic mice tumor growth model injected subcutaneously with IκBα-super-repressor or vector-expressing human pancreatic ductal adenocarcinoma cells, Waters et al. demonstrated that stable IκBα-super-repressor expression in vivo potentiated the antitumor effects of gemcitabine, resulting in decreased tumor growth in association with decreased cell proliferation [93]. The gene discussed is NFKBIA; the disease is pancreatic ductal adenocarcinoma.