Yang et al., by hypoxia inducible factor 2 alpha (HIF-2α) immunohistochemistry on pancreatic cancer patients and by HIF-2α-induced vasculogenic mimicry in vitro and in vivo experiments, demonstrated that HIF-2α overexpression and vasculogenic mimicry are correlated with poor tumor differentiation, late clinical stage, lymph node metastasis, and poor prognosis [23]. This evidence concerns the gene EPAS1 and familial pancreatic carcinoma.