KDR and pancreatic neuroendocrine tumor: In this context, Allen et al. demonstrated that treatment with anti-VEGFR2 and anti–programmed cell death ligand 1 antibodies induced high endothelial venules in RIP1-Tag2 transgenic mouse model of pancreatic neuroendocrine tumors that in turn promoted lymphocyte infiltration and activity through activation of lymphotoxin β receptor signalling [72].