This idea comes from the two facts; (i) Ras scaffolding protein KSR1 is a ceramide-binding protein requiring low levels of ceramide for membrane translocation to trigger the Ras signaling via EGFR [111,112] and (ii) nSMase inhibitor GW4869 thoroughly abrogates activation of ERK and p38 MAP kinases MAPKs in rat glioma C6 cells stimulated by phytochemicals, pent-acetyl geniposide [113] or caffeic acid phenethyl ester (CAPE) [114]. Here, SMPD2 is linked to central nervous system cancer.