Annual rates of development from chronic hepatitis B to liver cirrhosis ranged from 2.1 to 6.0% [18,19,20,21], and annual rates of the development of liver cirrhosis in HBV e antigen (HBeAg)-positive or anti-HBe-positive patients were 2.4% and 1.3%, respectively [18]. This evidence concerns the gene HBE1 and cirrhosis of liver.