In brain biopsies from patients with CNS TB, MMP-1 secretion was highest in the granuloma, and elevated concentrations of MMP-1 and -3 were associated with microglia in the peri-granuloma region and surrounding brain parenchyma and p38 positive microglia infiltrating necrotizing TB granulomas [20,91]. Here, MMP1 is linked to Granuloma.