PTEN mutations are associated with an increased activity of the signature of copy neutral LOH, CNS4 (Kruskal-Wallis test, p = 3.9 × 10−3, q = 4.3 × 10−2), and activity of CNS4 is also correlated with tumor mutational burden (linear regression, p = 5.3 × 10−3, q = 5.1 × 10−2). Here, PTEN is linked to neoplasm.