RB1 and cancer: Copy-number calling (Table S2) followed by recurrent copy-number analysis revealed significant recurrent altered regions of the USARC genome including amplification of the known sarcoma driver oncogenes JUN and RICTOR, and deletion of cancer driver genes such as TP53, RB1, CDKN2A, CBFA2T3, STK11, TCF3, and CYLD (GISTIC, q < 0.1; Figure 2A; Table S2).