SIRT3 deficiency dramatically exacerbates the degeneration of nigro‐striatal dopaminergic neurons in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinson Disease mice.19 Overexpression of SIRT3 decreases the excitotoxicity of N‐methyl‐d‐aspartic acid (NMDA) to the cultured mouse cortical neurons.20 Here, SIRT3 is linked to Parkinson disease.