Moreover, basic fibroblast growth factor (bFGF) is a growth factor that is known to promote fibroblast cell proliferation and bone formation.10, 11 bFGF promotes the formation of new periodontal tissue when applied in a dog alveolar bone defect model,12, 13 and significantly enhances new alveolar bone formation in chronic periodontitis patients in randomized clinical trials.14, 15. This evidence concerns the gene FGF2 and periodontitis.