HDAC2 and Aicardi-Goutieres syndrome: The identification of these interactions therefore raises the possibility that the efficient repair of ribonucleotides in vivo may require associated changes in chromatin structure (namely, demethylation by KDM1A/LSD1 and deacetylation by HDAC2), or vice versa, and that failure to co-ordinate these processes in humans may contribute to the inflammatory brain disorder AGS.