HMGCR and endometriosis: The anti-angiogenesis and anti-inflammatory effects of high-dose atorvastatin, via inhibition of HMG-CoA reductase (Park et al. 2002; Vincent et al. 2002), have also been demonstrated in endometriosis, in which both VEGF and angiogenesis have been implicated (Oktem et al. 2007).