New FAM3C‐YY1 pathway also provides an explanation for the findings that TGFβ induces HSF1 expression with unclear mechanism in ovarian and breast cancer cells.45, 46 Interestingly, although YY1‐HSF1 pathway plays an important role in activating Akt, it has also been reported that Akt activation also activates YY1 and HSF1 expressions.47, 48 TGFβ activated FAM3C‐YY1‐HSF1 axis to promote proliferation and migration in various breast cancer cell lines. The gene discussed is FAM3C; the disease is breast cancer.