However, with the progression of tumours, suppressive effects of TGF‐β have been circumvented and tumour cells take advantage of TGFβ family to acquire a mesenchymal phenotype.6, 7 As for EMT, it is demonstrated that EMT is activated via the TGFβ/Smad‐dependent pathway in several cell lines. The gene discussed is TGFB1; the disease is neoplasm.