In colorectal cancer, BMP‐2, an inducer of BMP signalling, induces EMT and drug resistance.38 BMP‐2 also induces BMP signalling and EMT in pancreatic cancer.39 The agonists of BMP‐2 and BMP‐7 also block the BMP signal, and inhibit EMT and invasion in melanoma cells.40 PMEPA1, which activates BMP signalling pathway like BMP‐2 and BMP7, might have the potential to be a novel target for molecular agonists design. This evidence concerns the gene PMEPA1 and pancreatic neoplasm.