Prostate transmembrane protein androgen induced 1 (PMEPA1) is highly expressed in most of cancers, like lung cancer, breast cancer and prostate cancer.9, 17, 19, 20, 21, 33 And we found that the expression of PMEPA1 was significantly up‐regulated in CRC samples of the TCGA and GEO databases, which indicated PMEPA1 might play an oncogenic roles in CRC. This evidence concerns the gene PMEPA1 and prostate carcinoma.