Prolonged hyperglycaemia is largely responsible for the development of NPDR.1 Apoptotic death of vascular cells mediated by hyperglycaemia in early DR will cause vascular abnormalities.16 Thounaojam et  al reported that STZ‐rats treated with MR‐409, a growth hormone‐releasing hormone (GHRH) agonist that could prevent retinal morphological alteration, were able to sustain the survival of retinal ganglion cells. The gene discussed is GHRH; the disease is Hyperglycemia.