The results showed that after interfering with FER1L4, the E2F1 expression was down‐regulated, the P21expression was up‐regulated, the cyclinD2 expression was significantly down‐regulated and the ERK phosphorylation was significantly reduced (Figure 5C‐E) suggesting that P21 can be up‐regulated and that cyclinD2 and ERK phosphorylation can be down‐regulated by down‐regulating FER1L4 targeted E2F1 in glioma cells, so as to inhibit the growth and proliferation of glioma cells. Here, E2F1 is linked to glioma.