Previous work demonstrated that PKM2, a preferred splice isoform of pyruvate kinase in cancer cells that converts phosphoenolpyruvate (PEP) to pyruvate as the final step of glycolysis, is critical for aerobic glycolysis in cancer cells (Christofk et al., 2008a; Christofk et al., 2008b; Yang and Lu, 2015; Dayton et al., 2016). Here, PKM is linked to cancer.