CD4 and neoplasm: Mice responsive to checkpoint inhibition had significantly higher levels of CD8+ TILs and TME PD-L1 expression but lower levels of CD11b+CD11c+ suppressive myeloid cells compared to nonresponders, while increases in RORγT+ Th17 tumor-infiltrating cells and regulatory CD4+ FoxP3+ T-cells and CD4+ IL-17+ T-cells were observed in nonresponders [19].