A meta-analysis of six trials reported that TNF-α inhibitor treatment continuation, in RA patients in sustained remission or low disease activity, increased the probability of low disease activity (relative risk [RR] = 0.66, 95% CI 0.51–0.84) and remission (0.57, 95% CI 0.44–0.74), and reduced radiographic progression (RR = 0.91, 95% CI 0.85–0.98) [25]. This evidence concerns the gene TNF and rheumatoid arthritis.