Analogous to AOSD, IL-18 serum levels in active sJIA (median = 21,512 pg/ml) were significantly higher than in the non-sJIA control group with elevated CRP (median = 2855 pg/ml; p = 0.002) although there was no difference in CRP levels between the two groups (p = 1.000). The gene discussed is IL18; the disease is adult-onset Still disease.