The second study, by Scott et al. [7], compared SF-36 health profiles in 205 English RA patients enrolled to the TACIT trial (of combination DMARDs vs. anti-TNF) at the trial end-point of 12-months, stratified by disease activity status (captured using the DAS28); lower HRQoL was seen in all domains in patients in remission, with the exception of mental health. This evidence concerns the gene TNF and rheumatoid arthritis.