In particular, novel inflammatory mediators with their associated cell signaling events have now been proven to have a role in experimental arthritis and in RA, including members of the IL-1 (IL-33, IL-36, IL-37, IL-38) and IL-12 (IL-27, IL-35) superfamilies, and other cytokines such as IL-32, IL-34. This evidence concerns the gene IL1B and arthritic joint disease.