IL-32β, δ, and γ mRNA overexpression in RA FLS is primarily induced by TNF-α, IFN-γ and toll-like receptor (TLR)-2, −3, and −4 ligands, and the overexpression of IL-32 seems to stabilize the mRNA transcripts of other cytokines, in particular TNF-α, IL-1β and IL-8 [110, 126]. This evidence concerns the gene IL32 and rheumatoid arthritis.