ERBB2 and cancer: GBR-1302 is a kind of BEAT BsAbs, targeting HER2 and CD3 for the treatment of HER2-positive cancers in clinical phase I (Table 1), which has the function of recruiting cytotoxic T lymphocytes (CTLs) to HER2 expressing tumor cells and activates CTLs to kill tumor cells at a very low concentration [40].