OMP-305B83 generated by this platform is a BsAb targeting Notch pathway ligand delta-like ligand 4 (DLL4) and VEGF, which is undergoing a phase 1a clinical study for patients with previously treated solid tumors (including ovarian cancer, endometrial cancer, breast cancer, and pancreatic cancer) (Table 1). This evidence concerns the gene DLL4 and endometrial cancer.